Liverpool have a large and very loyal fanbase, with virtually all home matches selling out; in 2006-07 Liverpool had the fourth-highest average League attendance for an English club; 43,561, which was 99.7% of available capacity, and the second-highest all-time average attendance. Liverpool fans often refer to themselves as "Kopites", which is a reference to the fans who once stood, and now sit, on the Kop at Anfield.

The song "You'll Never Walk Alone", originally from the Rodgers and Hammerstein musical Carousel and famously recorded by Liverpool musicians Gerry & The Pacemakers, is the anthem of the club, and has been sung by the Anfield crowd since the early 1960s. The song has since gained popularity among fans of other clubs around the world. The song's title adorns the top of the Shankly Gates, which were unveiled on 2 August 1982 in memory of former manager, Bill Shankly. The "You'll Never Walk Alone" portion of the Shankly Gates is also reproduced in the club's crest. Popular chants include "The Fields of Anfield Road" (to the tune of "The Fields of Athenry"), "Poor Scouser Tommy" (first section to the tune of "Red River Valley"; second section to the tune of "The Sash") and "Liverbird Upon My Chest" (to the tune of "Ballad of the Green Berets").

Liverpool's longest standing rivalry is with fellow Merseyside team Everton, against whom they contest the Merseyside derby. This stems from Liverpool's formation after a dispute with Everton officials and the owners of Anfield, which was the ground Everton were using at the time. Religious differences have been cited as a division, though both teams stem from a Methodist origin, undermining the notion of a Catholic-Protestant split. The Merseyside derby is usually a sell out fixture and tends to be a scrappy affair; it has had more red cards than any other fixture in Premiership history.

Liverpool also have a significant rivalry with north-west neighbours Manchester United. This is mostly due to the success enjoyed by the two clubs and the geographical proximity of the two cities. Liverpool and Manchester United are the two most successful teams in England, both with large international support. Liverpool dominated English football from the mid 1970s through the 1980s with 11 titles in 18 years, and they also won four European Cups in the period plus another in 2005, while Manchester United have dominated the Premier League era from 1992 with ten titles in 16 years to 2008, with two UEFA Champions League.